SCREENING METHOD OF ANTI-AGING AGENT

To provide a method for screening an anti-aging agent.SOLUTION: A screening method of an anti-aging agent which has a change of endoplasmic reticulum stress in a cell as an index, where the cell is an epidermal cell or a dermal fibroblast. Preferably, the screening method has a reduction of endoplas...

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Bibliographische Detailangaben
Hauptverfasser:	YO KAZUYUKI, SHISHIDO MAYUMI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a method for screening an anti-aging agent.SOLUTION: A screening method of an anti-aging agent which has a change of endoplasmic reticulum stress in a cell as an index, where the cell is an epidermal cell or a dermal fibroblast. Preferably, the screening method has a reduction of endoplasmic reticulum stress in the cell as an index, more preferably, the screening method includes the steps of: adding a test substance to the cell; and selecting a test substance in which the endoplasmic reticulum stress in the cell to which the test substance is added is lower than the endoplasmic reticulum stress in the cell to which the test substance is not added.SELECTED DRAWING: None 【課題】抗老化剤をスクリーニングする方法を提供することを課題とする。【解決手段】細胞における小胞体ストレスの変化を指標とする、抗老化剤のスクリーニング方法であって、前記細胞が、表皮細胞又は真皮線維芽細胞である、スクリーニング方法。好ましくは、細胞における小胞体ストレスの低減を指標とし、より好ましくは、前記スクリーニング方法は、被験物質を細胞に添加する工程、並びに被験物質を添加した細胞における前記小胞体ストレスが、被験物質を添加しなかった細胞における前記小胞体ストレスと比較して低い被験物質を選択する工程、を含む。【選択図】なし