CRYSTAL FORM OF TETRAHYDRO-N,N-DIMETHYL-2,2-DIPHENYL-3-FURANMETHANAMINE HYDROCHLORIDE, METHOD OF MAKING SUCH FORM, AND THEIR PHARMACEUTICAL COMPOSITION

To provide crystal forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, a method of making such forms, and their pharmaceutical composition.SOLUTION: Polymorphic forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) and a metabolite of...

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Hauptverfasser:	LINDA SHARON DAINTREE, ALANI SELVEY, DANIEL MARK LEDGER, LUCY ANNE LEONARD, PETER YORK
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	To provide crystal forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, a method of making such forms, and their pharmaceutical composition.SOLUTION: Polymorphic forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) and a metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) are disclosed and characterized. Compositions and method for treatment of Alzheimer's disease that includes the polymorphic forms and metabolite of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) are also provided.SELECTED DRAWING: None 【課題】テトラヒドロ－Ｎ，Ｎ－ジメチル－２，２－ジフェニル－３－フランメタンアミンヒドロクロリドの結晶形態、かかる形態の作製方法およびその薬学的組成物を提供すること。【解決手段】テトラヒドロ－Ｎ，Ｎ－ジメチル－２，２－ジフェニル－３－フランメタンアミンヒドロクロリド（ＡＮＡＶＥＸ２－７３）の多形形態およびテトラヒドロ－Ｎ，Ｎ－ジメチル－２，２－ジフェニル－３－フランメタンアミンヒドロクロリド（ＡＮＡＶＥＸ２－７３）の代謝産物が開示され、特徴付けられる。テトラヒドロ－Ｎ，Ｎ－ジメチル－２，２－ジフェニル－３－フランメタンアミンヒドロクロリド（ＡＮＡＶＥＸ２－７３）の多形形態および代謝産物を含むアルツハイマー病の処置のための組成物および方法。【選択図】なし