CHIMERIC ANTIGEN RECEPTOR

To provide a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, where the CAR comprises a Fab antigen binding domain.SOLUTION: The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR, an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SHAUN CORDOBA, SHIMOBI ONUOHA, MATHIEU FERRARI, EVANGELIA KOKALAKI, SIMON THOMAS, MARTIN PULE, MA BIAO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, where the CAR comprises a Fab antigen binding domain.SOLUTION: The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR, and therapeutic uses thereof. In a second aspect, there is provided a nucleic acid sequence which encodes a CAR according to the first aspect of the invention. In a third aspect, there is provided a nucleic acid construct which comprises a first nucleic acid sequence according to the second aspect of the invention, and a second nucleic acid sequence encoding a second chimeric antigen receptor which has a domain antibody (dAb) antigen binding domain or scFv antigen binding domain.SELECTED DRAWING: None 【課題】嵩高い細胞外ドメインを有する標的抗原に結合するキメラ抗原受容体（ＣＡＲ）であって、Ｆａｂ抗原結合ドメインを含む、キメラ抗原受容体（ＣＡＲ）を提供すること。【解決手段】本発明はまた、かかるＣＡＲをコードする核酸配列および構築物、かかるＣＡＲを発現する細胞、ならびにその治療における使用を提供する。第２の態様では、本発明の第１の態様のＣＡＲをコードする核酸配列を提供する。第３の態様では、本発明の第２の態様の第１の核酸配列、およびドメイン抗体（ｄＡｂ）抗原結合ドメインまたはｓｃＦｖ抗原結合ドメインを有する第２のキメラ抗原受容体をコードする第２の核酸配列を含む核酸構築物を提供する。【選択図】なし