CELL COLLECTING MATERIAL AND CELL COLLECTING COLUMN

To provide an immunosuppressive cell collecting material whose performance to selectively collect immunosuppressive cells is improved, and an immunosuppressive cell collecting column with which the cell collecting material is filled.SOLUTION: An immunosuppressive cell collecting material is provided...

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Hauptverfasser: TERAMOTO KAZUO, NAKAYAMA MISAKO, ISHIGAKI HIROHITO, ITO YASUSHI
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:To provide an immunosuppressive cell collecting material whose performance to selectively collect immunosuppressive cells is improved, and an immunosuppressive cell collecting column with which the cell collecting material is filled.SOLUTION: An immunosuppressive cell collecting material is provided on the surface with polymer having a substituent group expressed in a following general formula (1) in an aromatic residue group of a main chain and is composed of a polymer molded product, and an immunosuppressive cell collecting column is filled with the cell collecting material. φ-R-X-Y-Z (1)[in the formula, φ shows an aromatic nucleus of a main chain, R shows -CH2-, -CH2 NHCOCH2-, or -CH2 NHCOCH2CH2-, X shows -NH(CH2)n-A-(CH2)mNH-, n and m show 2 or 3 in the same way or differently, A shows -NH- or -NH-(CH2CH2)p-NH-, p shows integers 2 to 4, Y shows a carbonyl group, -CH2CONH- or -CH2CH2CONH- group, and Z shows a linear or branched-chain alkyl group with 3 to 8 carbon number.]SELECTED DRAWING: None 【課題】免疫抑制性細胞を選択的に捕集する性能が向上した免疫抑制性細胞捕集材、及び該捕集材が充填された免疫抑制性細胞捕集用カラムを提供する。【解決手段】主鎖の芳香族残基に以下の一般式(1)で表される置換基を有するポリマーを表面に備えた、ポリマーの成型体からなる免疫抑制性細胞捕集材、及び該捕集材が充填された免疫抑制性細胞捕集用カラム。φ-R-X-Y-Z (1)〔式中、φは主鎖の芳香核を示し、Rは-CH2-、-CH2NHCOCH2-、又は-CH2NHCOCH2CH2-を示し、Xは-NH(CH2)n-A-(CH2)mNH-を示し、n及びmは同一又は異なって2又は3を示し、Aは-NH-又は-NH-(CH2CH2)p-NH-を示し、pは2~4の整数を示し、Yはカルボニル基、-CH2CONH-又は-CH2CH2CONH-基を示し、Zは炭素数3~8の直鎖状又は分岐鎖状のアルキル基を示す。〕【選択図】なし