TAU MODULATORS, AND METHODS AND COMPOSITIONS FOR DELIVERY THEREOF

To provide tau modulators, and methods and compositions for delivery thereof.SOLUTION: The present disclosure is in a field of diagnostics and therapeutics for Alzheimer's disease regarding in vivo gene regulation of disease genes. Disclosed herein are methods and compositions for diagnosing, p...

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Hauptverfasser:	BRADLEY T HYMAN, SUSANNE WEGMANN, H STEVE ZHANG, ANNEMARIE LEDEBOER, SARAH DEVOS, BRYAN ZEITLER
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide tau modulators, and methods and compositions for delivery thereof.SOLUTION: The present disclosure is in a field of diagnostics and therapeutics for Alzheimer's disease regarding in vivo gene regulation of disease genes. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating one or more tauopathies, such as Alzheimer's disease (AD). In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) a tau allele so as to treat at least one tauopathy such as AD, including engineered transcription factor repressors (that repress tau expression).SELECTED DRAWING: None 【課題】タウモジュレーターならびにその送達のための方法および組成物の提供。【解決手段】本開示は、疾患遺伝子のｉｎｖｉｖｏ遺伝子調節に関する、アルツハイマー病の診断および治療の分野である。本明細書には、アルツハイマー病（ＡＤ）などの１つまたは複数のタウオパチーを診断、予防、および／または処置するための方法および組成物が開示されている。特に、本明細書には、遺伝子操作転写因子リプレッサー（タウ発現を抑制する）を含む、ＡＤなどの少なくとも１つのタウオパチーを処置するようにタウ対立遺伝子を修飾する（例えば、その発現を調節する）ための方法および組成物が提供されている。【選択図】なし