HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE

HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE

To provide compounds useful for the inhibition of Delta-5 Desaturase.SOLUTION: There is provided a compound of Formula I or a tautomer thereof, or a pharmaceutically acceptable salt of the compound or the tautomer, where R1 is O, S or NH, R2 is a substituted benzene ring or a 5-membered heteroaryl,...

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Bibliographische Detailangaben
Hauptverfasser: TEODORA P DAMYANOVA, IAIN LINGARD, PAOLO VINCETTI, MICHELA BELTRANI, ANA E MINATTI, MATTHEW P BOURBEAU, ALLEN JENNIFER R
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:To provide compounds useful for the inhibition of Delta-5 Desaturase.SOLUTION: There is provided a compound of Formula I or a tautomer thereof, or a pharmaceutically acceptable salt of the compound or the tautomer, where R1 is O, S or NH, R2 is a substituted benzene ring or a 5-membered heteroaryl, R4 is C1-3 alkyl or the like, and a group indicated with dashed lines forms a 5-membered ring with N and C.SELECTED DRAWING: None 【課題】デルタ－５デサチュラーゼの阻害に有用な化合物を提供する。【解決手段】式Ｉの化合物若しくはその互変異性体、又は前記化合物若しくは前記互変異性体の薬学的に許容される塩を提供する。TIFF2023078418000255.tif41170式中、Ｒ１はＯ、Ｓ、ＮＨ、Ｒ２は置換ベンゼン環、５員環ヘテロアリール、Ｒ４は、Ｃ１～３アルキル等、TIFF2023078418000256.tif19170基はＮ及びＣと共に５員環を形成する。【選択図】なし