COMPOSITIONS FOR ACTIVATING TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1

To provide novel agonists of transient receptor potential ankyrin 1 (TRPA1).SOLUTION: A composition for activating TRPA1 of the present invention contains oxylipin derived from lemongrass or a pharmaceutically acceptable salt thereof, or contains a compound represented by a formula (1) in the figure...

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Bibliographische Detailangaben
Hauptverfasser:	KAMOI TAKAHIRO, IWASAKI YUSAKU, NITTA TAKAHIRO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	To provide novel agonists of transient receptor potential ankyrin 1 (TRPA1).SOLUTION: A composition for activating TRPA1 of the present invention contains oxylipin derived from lemongrass or a pharmaceutically acceptable salt thereof, or contains a compound represented by a formula (1) in the figure (where n, A and B are as defined in the claims) or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: None 【課題】本発明は、一過性受容器電位アンキリン１（ＴＲＰＡ１）の新規アゴニストを提供することを目的としている。【解決手段】本発明のＴＲＰＡ１を活性化するための組成物は、レモングラス由来のオキシリピン又はその薬学的に許容可能な塩を含んでいるか、あるいは、式（１）：【化１】TIFF2023074001000038.tif2539（１）（式中のｎ、Ａ、及びＢは、特許請求の範囲で定義されているとおり）で表される化合物又はその薬学的に許容可能な塩を含んでいる。【選択図】なし