CRYSTAL OF AZABICYCLO RING COMPOUND

To provide a compound having KDM5 inhibitory activity and a suitable form thereof for pharmaceutical ingredients.SOLUTION: A compound disclosed herein has strong KDM5 inhibitory activity as well as excellent metabolic stability and also can exist in the brain at high concentrations, so that it is su...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	HIRAMATSU ATSUSHI, KAKUUCHI AKITO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To provide a compound having KDM5 inhibitory activity and a suitable form thereof for pharmaceutical ingredients.SOLUTION: A compound disclosed herein has strong KDM5 inhibitory activity as well as excellent metabolic stability and also can exist in the brain at high concentrations, so that it is suitable as an agent for preventing and/or treating KDM5-associated diseases, particularly, diseases such as cancer, Huntington's disease, Alzheimer's disease. The compound is also suitable as a pharmaceutical ingredient.SELECTED DRAWING: None 【課題】KDM5阻害活性を有する化合物およびその医薬品原薬に適した形態の提供。【解決手段】本開示の化合物は、強いKDM5阻害活性を有することに加えて、本化合物は代謝安定性に優れ、かつ高濃度で脳内に存在することができるため、KDM5が関与する疾患の予防および／または治療剤、特に、がん、ハンチントン病、アルツハイマー病等の疾患の予防および／または治療剤として有用である。また、本開示の化合物は、医薬品の原料として有用である。【選択図】なし