THERAPEUTICALLY TRIGGERING INNATE IMMUNE RESPONSE IN TARGET TISSUE

To provide therapeutic compositions that present an artificial repertoire of mammalian pattern recognition receptor (PRR) agonists so that the pattern of PRR agonists recapitulates a distinct portion of a PRR agonist signature of a mammalian pathogen.SOLUTION: The artificial repertoire of PRR agonis...

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Hauptverfasser:	DAVID W MULLINS, MOMIR BOSILJCIC, MARCEL THALEN, SHAM HO PAN, MARK BAZETT, SHIRIN KALYAN, HAROLD DAVID GUNN, MONAN ANGELA ZHANG, BOYKO TRAYCHEV KABAKCHIEV, DERMOT MCGOVERTN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide therapeutic compositions that present an artificial repertoire of mammalian pattern recognition receptor (PRR) agonists so that the pattern of PRR agonists recapitulates a distinct portion of a PRR agonist signature of a mammalian pathogen.SOLUTION: The artificial repertoire of PRR agonists may be formulated together in a therapeutic vehicle for combined presentation to an innate immune cell resident in a target tissue in a mammalian host, and such a vehicle is adapted to deliver the PRR agonists to the target tissue so as to modulate an immune response.SELECTED DRAWING: Figure 2 【課題】本発明は、パターン認識受容体（ＰＲＲ）アゴニストのパターンが、哺乳類病原体のＰＲＲアゴニストシグネチャーの異なる部分を再現するように哺乳類ＰＲＲアゴニストの人工レパートリーを提示する治療組成物を提供する。【解決手段】ＰＲＲアゴニストの人工レパートリーは、哺乳類宿主の標的組織に常在する自然免疫細胞に対して組み合わさって提示されるように治療媒体において一緒に製剤化され得、こうした媒体は、免疫応答が調節されるようにＰＲＲアゴニストを標的組織に送達することに適したものである。【選択図】図２