PRODUCTION METHOD OF 4-BROMOISOTHIAZOLINONE DERIVATIVE AND 4-BROMOISOTHIAZOLINONE DERIVATIVE

PRODUCTION METHOD OF 4-BROMOISOTHIAZOLINONE DERIVATIVE AND 4-BROMOISOTHIAZOLINONE DERIVATIVE

To provide a method for selectively producing a high-purity 4-bromoisothiazolinone derivative at a good yield.SOLUTION: Provided is a method for producing a 4-bromoisothiazolinone derivative represented by formula (1) (in which R is a hydrogen atom or a C1-12 alkyl group). The method involves using...

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Hauptverfasser: YOKOI TAIYO, TACHIMOTO TOMOKO, SOMEYA SHINTARO, MORITA SHIGEO, NAKAMURA SHINJI, ARAKI CHIHARU, KOBAYASHI OSAMU, KATO AYUMI
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:To provide a method for selectively producing a high-purity 4-bromoisothiazolinone derivative at a good yield.SOLUTION: Provided is a method for producing a 4-bromoisothiazolinone derivative represented by formula (1) (in which R is a hydrogen atom or a C1-12 alkyl group). The method involves using a brominating agent to brominate an isothiazolinone compound represented by formula (2) (in which R is the same as in formula (1)) or a chemically acceptable salt thereof in an aqueous solvent or a mixed solvent of an aqueous solvent and an organic solvent.SELECTED DRAWING: None 【課題】高純度の４－ブロモイソチアゾリノン誘導体を、選択性および収率よく製造する方法を提供する。【解決手段】式（１）JPEG2023036512000018.jpg22170（式中、Ｒは、水素原子または炭素数１～１２のアルキル基を表す。）で示される４－ブロモイソチアゾリノン誘導体を製造する方法であって、式（２）JPEG2023036512000019.jpg22170（式中、Ｒは、式（１）と同じである。）で示されるイソチアゾリノン化合物またはその化学的に許容される塩を、水溶媒中または水溶媒と有機溶媒との混合溶媒中で臭素化剤を用いて臭素化する、４－ブロモイソチアゾリノン誘導体の製造方法である。【選択図】なし