METHODS IN WHICH PRESENCE OR ABSENCE OF AMYLOID β ACCUMULATION RISK IS USED AS INDICATOR AS WELL AS METHODS, COMPOSITIONS, AND KITS FOR DETECTING PRESENCE OR ABSENCE OF SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS)

To provide methods for determining the risk of being likely to develop Alzheimer's dementia even in an early stage before the onset of Alzheimer's dementia, besides methods focusing solely on the ApoE4 gene.SOLUTION: Provided is a method in which the presence or absence of a single nucleot...

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Hauptverfasser:	KATSUYAMA TOYOYO, YAMAMOTO MARI, SATO KOJI, NISHIHIRA JUN, UEJIMA KIMI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	To provide methods for determining the risk of being likely to develop Alzheimer's dementia even in an early stage before the onset of Alzheimer's dementia, besides methods focusing solely on the ApoE4 gene.SOLUTION: Provided is a method in which the presence or absence of a single nucleotide polymorphism (SNP) rs4907405 on human chromosome region 8q24.3 in a subject-derived nucleic acid is used as an indicator of the presence or absence of amyloid β accumulation risk in the subject.SELECTED DRAWING: None 【課題】ＡｐｏＥ４遺伝子のみに主眼が置かれた方法以外に、アルツハイマー型認知症の発症前の初期段階においても、アルツハイマー型認知症を発症しやすいというリスクを判定する方法を提供すること。【解決手段】被験者由来の核酸におけるヒト染色体領域８ｑ２４．３上の一塩基多型（ＳＮＰ）ｒｓ４９０７４０５の存在又は非存在を該被験者におけるアミロイドβ蓄積リスクの有無の指標とする方法。【選択図】なし