SOLID PREPARATION CONTAINING IBUPROFEN

To provide a solid preparation having excellent dissolution of ibuprofen and a good color tone.SOLUTION: A solid preparation includes a granular product containing the following ingredients (a1), (a2), (a3), and (a4): (a1) ibuprofen or a salt thereof or a solvate thereof; (a2) magnesium oxide; (a3)...

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Bibliographische Detailangaben
Hauptverfasser:	KONUKI YOICHI, YOSHIMURA TADASHI, YOSHIDA MIA, SHIBOZAWA RINA
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide a solid preparation having excellent dissolution of ibuprofen and a good color tone.SOLUTION: A solid preparation includes a granular product containing the following ingredients (a1), (a2), (a3), and (a4): (a1) ibuprofen or a salt thereof or a solvate thereof; (a2) magnesium oxide; (a3) sodium lauryl sulfate; and (a4) one or more disintegrating agents selected from the group consisting of low substituted hydroxypropylcellulose, sodium carboxymethyl starch, carmellose, carmellose calcium, crospovidone, and croscarmellose sodium.SELECTED DRAWING: None 【課題】イブプロフェンの溶出性に優れ、且つ色調が良好な固形製剤を提供すること。【解決手段】以下の成分（ａ１）、（ａ２）、（ａ３）及び（ａ４）を含有する造粒物を含む、固形製剤。（ａ１）イブプロフェン若しくはその塩又はそれらの溶媒和物（ａ２）酸化マグネシウム（ａ３）ラウリル硫酸ナトリウム（ａ４）低置換度ヒドロキシプロピルセルロース、カルボキシメチルスターチナトリウム、カルメロース、カルメロースカルシウム、クロスポビドン及びクロスカルメロースナトリウムから選ばれる１種以上の崩壊剤【選択図】なし