PHARMACEUTICAL PREPARATION, AND METHOD FOR PRODUCING THE SAME
To provide granules that include non-volatile solvent such as surfactant and vitamins useful for production of a medicine, and have excellent flowability durable for actual production.SOLUTION: A pharmaceutical preparation of a granule form comprises nuclear particles and a coating layer coating the...
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| Zusammenfassung: | To provide granules that include non-volatile solvent such as surfactant and vitamins useful for production of a medicine, and have excellent flowability durable for actual production.SOLUTION: A pharmaceutical preparation of a granule form comprises nuclear particles and a coating layer coating the nuclear particles, in which the nuclear particles include a medicine, a nuclear particle component and non-volatile solvent, a BET specific surface area of the nuclear particle component is 0.45 m2/g or more, and the content of the non-volatile solvent per unit mass of the pharmaceutical preparation is 10 mg or more.SELECTED DRAWING: None
【課題】本発明によれば、界面活性剤やビタミン類等の医薬品製造に有用な不揮発性溶媒を含み、実際の製造に耐え得る優れた流動性を有する顆粒を提供することができる。【解決手段】核粒子と該核粒子を被覆する被覆層とを備える顆粒形態の医薬製剤であって、前記核粒子が、薬物、核粒子成分および不揮発性溶媒を含んでなり、前記核粒子成分のＢＥＴ比表面積が０．４５ｍ２／ｇ以上であり、前記医薬製剤の単位質量当たりの前記不揮発性溶媒の含有量が１０ｍｇ以上である、前記医薬製剤。【選択図】なし |
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