TISSUE STRUCTURE EVALUATION SYSTEM AND SAMPLE IMAGE CAPTURING METHOD

To provide a tissue structure evaluation system capable of detecting fluctuations caused by an image capturing device.SOLUTION: A tissue structure evaluation device 10 includes a feature quantity extraction unit 13 that extracts a first feature quantity from a captured image captured while changing an observation field of view on a sample 4 by an image capturing device, and a fluctuation evaluation unit 14 that calculates the long-term fluctuation of the first feature quantity, returns the observation field of view to the position before the occurrence of the long-term fluctuation and perform re-capturing to acquire a re-captured image, calculates a difference between the first feature amount of the captured image and the first feature amount of the re-captured image at the position before the occurrence of the long-term fluctuation when the long-term fluctuation exceeds a predetermined standard, and a variation evaluation unit determines that the long-term fluctuation is due to a sample when the difference is less than a predetermined threshold, and determines that the long-term fluctuation is due to the image capturing device when the difference is greater than or equal to the predetermined threshold.SELECTED DRAWING: Figure 12 【課題】撮像装置に起因する変動をサンプル画像から検出可能な組織構造評価システムを提供する。【解決手段】組織構造評価装置１０は、撮像装置１によりサンプル４上の観察視野を変えながら撮像した撮像画像から第１の特徴量を抽出する特徴量抽出部１３と、第１の特徴量の長期変動を算出し、長期変動が所定の基準を超える場合には、長期変動の発生前の位置に観察視野を戻して再撮像して再撮像画像を取得し、長期変動の発生前の位置での撮像画像の第１の特徴量と再撮像画像の第１の特徴量との差を算出する変動評価部１４とを備え、変動評価部は、差が所定の閾値未満である場合には長期変動はサンプルに起因する変動であると判定し、差が所定の閾値以上である場合には長期変動は撮像装置に起因する変動であると判定する。【選択図】図１２