ENDOSTATIN FRAGMENTS AND VARIANTS FOR USE IN TREATING FIBROSIS

To provide materials and methods for treating fibrosis, in particular polypeptides containing fragments and variants of endostatin to treat fibrosis.SOLUTION: The present invention discloses an isolated polypeptide, wherein the polypeptide: a) comprises an amino acid sequence consisting of a specifi...

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Bibliographische Detailangaben
Hauptverfasser:	MATTHEW MCGEE, HAL S PADGETT, TERENCE E RYAN, BARRY R HOLTZ, CAROL FEGHALI-BOSTWICK
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide materials and methods for treating fibrosis, in particular polypeptides containing fragments and variants of endostatin to treat fibrosis.SOLUTION: The present invention discloses an isolated polypeptide, wherein the polypeptide: a) comprises an amino acid sequence consisting of a specific sequence; and b) has anti-fibrotic activity when administered to a subject in need thereof.SELECTED DRAWING: Figure 1A 【課題】線維症を治療するための材料および方法、特に、線維症を治療するための、エンドスタチンの断片およびバリアントを含有するポリペプチドを提供する。【解決手段】ａ）特定の配列からなるアミノ酸配列を含み、ｂ）それを必要とする対象に投与された場合に抗線維化活性を有する、単離されたポリペプチドを提供する。【選択図】図１Ａ