METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS

To provide methods of treating metabolic diseases and metabolic disorders using an antigen binding protein specific for the GIPR polypeptide.SOLUTION: A method of treating a subject with a metabolic disorder comprises administering to the subject a therapeutically effective amount of an antigen bind...

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Hauptverfasser:	YIE JUNMING, HO SHU-YIN, MIN XIAOSHAN, GLENN N SIVITS JR, SHI DONGHUI, DAVID J LLOYD, DARREN L BATES, RENEE KOMOROWSKI, IAN N FOLTZ, NEERAJ AGRAWAL, WANG ZHULUN, CHRISTOPHER MURAWSKY, BRANDON C P CLAVETTE, WANG JINGHONG, VENIANTMURIELLE M -ELLISON
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide methods of treating metabolic diseases and metabolic disorders using an antigen binding protein specific for the GIPR polypeptide.SOLUTION: A method of treating a subject with a metabolic disorder comprises administering to the subject a therapeutically effective amount of an antigen binding protein that specifically binds to a protein having an amino acid sequence having at least 90% amino acid sequence identity to an amino acid sequence of a GIPR. The metabolic disorder is a disorder of glucose metabolism, and the plasma glucose in the subject is reduced.SELECTED DRAWING: None 【課題】ＧＩＰＲポリペプチドに特異的な抗原結合タンパク質を使用する、代謝疾患及び代謝障害の治療方法を提供する。【解決手段】代謝障害を有する対象の治療方法であって、ＧＩＰＲのアミノ酸配列に対して少なくとも９０％のアミノ酸配列同一性を有するアミノ酸配列を有するタンパク質に特異的に結合する抗原結合タンパク質の、治療的に有効な量での前記対象への投与を含む方法である。前記代謝障害は、グルコース代謝の障害であり、前記対象における血漿グルコースを低減する。【選択図】なし