METHOD FOR PREPARING DIHYDROQUINOLINONE COMPOUND
To provide methods for preparing 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on.SOLUTION: Methods for preparing crystals of 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dih...
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| creator | OKAMURA FUMIYA KEMMOCHI SUGURU ANNAKA KIMIYOSHI MITANI HIKARI OTSUKA REI FUJII TAKUYA |
| description | To provide methods for preparing 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on.SOLUTION: Methods for preparing crystals of 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on are provided which includes the steps of: (1) recycling 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on in a solvent acceptable for preparing pharmaceutical preparations; and (2) cooling and then stirring a solution obtained through the recycling step (1) to obtain the crystal.SELECTED DRAWING: None
【課題】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの製造方法の提供。【解決手段】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの結晶の製造方法であって、（１）５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンを医薬品製造に許容される溶媒中で還流する工程、及び（２）前記還流工程（１）で得られた溶液を冷却して撹拌することにより前記結晶を得る工程を含む方法が提供される。【選択図】なし |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JP2021178818A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JP2021178818A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JP2021178818A3</originalsourceid><addsrcrecordid>eNrjZDDwdQ3x8HdRcPMPUggIcg1wDPL0c1dw8fSIdAnyDwz19PP3AWI_VwVnf98A_1A_Fx4G1rTEnOJUXijNzaDk5hri7KGbWpAfn1pckJicmpdaEu8VYGRgZGhobmFhaOFoTJQiAKV9JzA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD FOR PREPARING DIHYDROQUINOLINONE COMPOUND</title><source>esp@cenet</source><creator>OKAMURA FUMIYA ; KEMMOCHI SUGURU ; ANNAKA KIMIYOSHI ; MITANI HIKARI ; OTSUKA REI ; FUJII TAKUYA</creator><creatorcontrib>OKAMURA FUMIYA ; KEMMOCHI SUGURU ; ANNAKA KIMIYOSHI ; MITANI HIKARI ; OTSUKA REI ; FUJII TAKUYA</creatorcontrib><description>To provide methods for preparing 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on.SOLUTION: Methods for preparing crystals of 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on are provided which includes the steps of: (1) recycling 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on in a solvent acceptable for preparing pharmaceutical preparations; and (2) cooling and then stirring a solution obtained through the recycling step (1) to obtain the crystal.SELECTED DRAWING: None
【課題】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの製造方法の提供。【解決手段】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの結晶の製造方法であって、（１）５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンを医薬品製造に許容される溶媒中で還流する工程、及び（２）前記還流工程（１）で得られた溶液を冷却して撹拌することにより前記結晶を得る工程を含む方法が提供される。【選択図】なし</description><language>eng ; jpn</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211118&DB=EPODOC&CC=JP&NR=2021178818A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211118&DB=EPODOC&CC=JP&NR=2021178818A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OKAMURA FUMIYA</creatorcontrib><creatorcontrib>KEMMOCHI SUGURU</creatorcontrib><creatorcontrib>ANNAKA KIMIYOSHI</creatorcontrib><creatorcontrib>MITANI HIKARI</creatorcontrib><creatorcontrib>OTSUKA REI</creatorcontrib><creatorcontrib>FUJII TAKUYA</creatorcontrib><title>METHOD FOR PREPARING DIHYDROQUINOLINONE COMPOUND</title><description>To provide methods for preparing 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on.SOLUTION: Methods for preparing crystals of 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on are provided which includes the steps of: (1) recycling 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on in a solvent acceptable for preparing pharmaceutical preparations; and (2) cooling and then stirring a solution obtained through the recycling step (1) to obtain the crystal.SELECTED DRAWING: None
【課題】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの製造方法の提供。【解決手段】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの結晶の製造方法であって、（１）５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンを医薬品製造に許容される溶媒中で還流する工程、及び（２）前記還流工程（１）で得られた溶液を冷却して撹拌することにより前記結晶を得る工程を含む方法が提供される。【選択図】なし</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDwdQ3x8HdRcPMPUggIcg1wDPL0c1dw8fSIdAnyDwz19PP3AWI_VwVnf98A_1A_Fx4G1rTEnOJUXijNzaDk5hri7KGbWpAfn1pckJicmpdaEu8VYGRgZGhobmFhaOFoTJQiAKV9JzA</recordid><startdate>20211118</startdate><enddate>20211118</enddate><creator>OKAMURA FUMIYA</creator><creator>KEMMOCHI SUGURU</creator><creator>ANNAKA KIMIYOSHI</creator><creator>MITANI HIKARI</creator><creator>OTSUKA REI</creator><creator>FUJII TAKUYA</creator><scope>EVB</scope></search><sort><creationdate>20211118</creationdate><title>METHOD FOR PREPARING DIHYDROQUINOLINONE COMPOUND</title><author>OKAMURA FUMIYA ; KEMMOCHI SUGURU ; ANNAKA KIMIYOSHI ; MITANI HIKARI ; OTSUKA REI ; FUJII TAKUYA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2021178818A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OKAMURA FUMIYA</creatorcontrib><creatorcontrib>KEMMOCHI SUGURU</creatorcontrib><creatorcontrib>ANNAKA KIMIYOSHI</creatorcontrib><creatorcontrib>MITANI HIKARI</creatorcontrib><creatorcontrib>OTSUKA REI</creatorcontrib><creatorcontrib>FUJII TAKUYA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OKAMURA FUMIYA</au><au>KEMMOCHI SUGURU</au><au>ANNAKA KIMIYOSHI</au><au>MITANI HIKARI</au><au>OTSUKA REI</au><au>FUJII TAKUYA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR PREPARING DIHYDROQUINOLINONE COMPOUND</title><date>2021-11-18</date><risdate>2021</risdate><abstract>To provide methods for preparing 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on.SOLUTION: Methods for preparing crystals of 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on are provided which includes the steps of: (1) recycling 5-{[(3R, 4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidine-4-yl] methoxy}-8-fluoro-3,4-dihydroquinoline-2(1H)-on in a solvent acceptable for preparing pharmaceutical preparations; and (2) cooling and then stirring a solution obtained through the recycling step (1) to obtain the crystal.SELECTED DRAWING: None
【課題】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの製造方法の提供。【解決手段】５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンの結晶の製造方法であって、（１）５−｛［（３Ｒ，４Ｒ）−１−（４−クロロ−２，６−ジフルオロフェニル）−３，４−ジヒドロキシピペリジン−４−イル］メトキシ｝−８−フルオロ−３，４−ジヒドロキノリン−２（１Ｈ）−オンを医薬品製造に許容される溶媒中で還流する工程、及び（２）前記還流工程（１）で得られた溶液を冷却して撹拌することにより前記結晶を得る工程を含む方法が提供される。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD FOR PREPARING DIHYDROQUINOLINONE COMPOUND |
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