ANTIBODIES THAT BIND TO NERVE PRECURSOR CELLS

To provide novel antibodies that bind to nerve precursor cells.SOLUTION: Disclosed is an antibody that binds to a nerve precursor cell, the antibody comprising a heavy chain variable region comprising HCDR1 of a specific amino acid sequence, HCDR2 of a specific amino acid sequence and HCDR3 of a specific amino acid sequence, and a light chain variable region comprising LCDR1 of a specific amino acid sequence, LCDR2 of a specific amino acid sequence and LCDR3 of a specific amino acid sequence. Also disclosed are an isolated nucleic acid comprising a nucleotide sequence encoding the antibody, an expression vector comprising the nucleic acid, a host cell comprising the expression vector and a method for preparing a cell population containing nerve precursor cells comprising a step of recovering cells to which the antibody has bound.SELECTED DRAWING: None 【課題】神経前駆細胞に結合する新規抗体の提供。【解決手段】特定のアミノ酸配列を含むＨＣＤＲ１、特定のアミノ酸配列を含むＨＣＤＲ２、特定のアミノ酸配列を含むＨＣＤＲ３を含む重鎖可変領域、及び特定のアミノ酸配列を含むＬＣＤＲ１、特定のアミノ酸配列を含むＬＣＤＲ２、特定のアミノ酸配列をＬＣＤＲ３を含む軽鎖可変領域を含む、神経前駆細胞に結合する抗体、該抗体をコードするヌクレオチド配列を含む単離された核酸、該核酸を含む発現ベクター、該発現ベクターを含む宿主細胞、並びに該抗体が結合した細胞を回収する工程を含む、神経前駆細胞を含む細胞群の調製方法。【選択図】なし