MONOCLONAL ANTIBODIES TO GROWTH AND DIFFERENTIATION FACTOR 15 (GDF-15), AND USES THEREOF FOR TREATING CANCER CACHEXIA AND CANCER

To provide monoclonal anti-human-GDF-15 antibodies.SOLUTION: The antibodies include chimeric antibodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine antibodies, chimeric antibodies and humanized antibodies for use in methods for the...

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Bibliographische Detailangaben
Hauptverfasser:	JOERG WISCHHUSEN, DIRK PUEHRINGER, TINA SCHAEFER, MARKUS JUNKER
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide monoclonal anti-human-GDF-15 antibodies.SOLUTION: The antibodies include chimeric antibodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine antibodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.SELECTED DRAWING: None 【課題】モノクローナル抗ヒトＧＤＦ−１５抗体を提供する。【解決手段】抗体は、キメラ抗体およびヒト化抗体を含む。本発明はまた、がん悪液質の処置のため、同様にがんの処置のため、の方法における使用のための、マウス抗体、キメラ抗体およびヒト化抗体を含む、モノクローナル抗ヒトＧＤＦ−１５抗体にも関する。本発明はまた、医薬組成物、キット、方法および使用ならびに本発明のモノクローナル抗体を産生可能な細胞株も提供する。【選択図】なし