β-AMINO ACID DERIVATIVE, KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION THAT CONTAIN THE SAME, AND USE OF THE SAME

β-AMINO ACID DERIVATIVE, KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION THAT CONTAIN THE SAME, AND USE OF THE SAME

To provide: a novel β-amino acid derivative; a kinase inhibitor and a pharmaceutical composition that contain the same; and use of the same.SOLUTION: The invention provides a compound represented by Formula (I), or a pharmaceutically acceptable salt, ester, hydrate, solvate or crystalline form there...

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Bibliographische Detailangaben
Hauptverfasser: FU CHIH-WEI, CHEN YI-HSUN, HUNG CHIU-LIEN, LIU CHIH-PENG, TU CHIA-MU
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:To provide: a novel β-amino acid derivative; a kinase inhibitor and a pharmaceutical composition that contain the same; and use of the same.SOLUTION: The invention provides a compound represented by Formula (I), or a pharmaceutically acceptable salt, ester, hydrate, solvate or crystalline form thereof. In the formula: X is a single bond or O; Y is NH or C=O; Z is C=O, C=S, NH, or the like; W is C or N; and A is a single bond, O, OH, OCH2, a heterocycle, or N3.SELECTED DRAWING: Figure 2 【課題】新規なβアミノ酸誘導体、これを含むキナーゼ阻害剤および医薬組成物ならびにその使用を提供する。【解決手段】式（Ｉ）で示される化合物またはその薬学的に許容される塩もしくはエステル、水和物、溶媒和物もしくは結晶形を提供する。式中：Ｘは単結合またはＯであり；ＹはＮＨまたはＣ＝Ｏであり；ＺはＣ＝Ｏ、Ｃ＝Ｓ、ＮＨ等であり；ＷはＣまたはＮであり；Ａは単結合、Ｏ、ＯＨ、ＯＣＨ２、複素環またはＮ３である。【選択図】図２