CRYSTALLINE FORM OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-f] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY)(PHENOXY) PHOSPHORYL)AMINO)PROPANOATE

CRYSTALLINE FORM OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-f] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY)(PHENOXY) PHOSPHORYL)AMINO)PROPANOATE

To provide novel salts and crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (hereinafter referred to as compound I) which have antiviral properties to viru...

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Hauptverfasser: LARS V HEUMANN, NATE LARSON, ERNEST A CARRA, KATRIEN BRAK
Format: Patent
Sprache:eng ; jpn
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:To provide novel salts and crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (hereinafter referred to as compound I) which have antiviral properties to viruses selected from the group comprising Arenaviridae, Coronaviridae, Filoviridae, and Paramyxoviridae viruses.SOLUTION: A crystalline form of a compound I is provided which can be characterized by an X-ray powder diffraction (XRPD) pattern having peaks at 22.3°, 16.9°, and 16.2°2θ±0.2°2θ.SELECTED DRAWING: Figure 1 【課題】Ａｒｅｎａｖｉｒｉｄａｅ、Ｃｏｒｏｎａｖｉｒｉｄａｅ、Ｆｉｌｏｖｉｒｉｄａｅ、およびＰａｒａｍｙｘｏｖｉｒｉｄａｅからなる群から選択されるウイルスに対して抗ウイルス特性を有す（Ｓ）−２−エチルブチル２−（（（Ｓ）−（（（２Ｒ，３Ｓ，４Ｒ，５Ｒ）−５−（４−アミノピロロ［２，１−ｆ］［１，２，４］トリアジン−７−イル）−５−シアノ−３，４−ジヒドロキシテトラヒドロフラン−２−イル）メトキシ）（フェノキシ）ホスホリル）アミノ）プロパノエート（以下、化合物Ｉと表す）の新規な塩および結晶形態を提供する。【解決手段】約２２．３°、１６．９°、および１６．２°２θ±０．２°２θにおいてピークを有するＸ線粉末回折（ＸＲＰＤ）パターンによって特徴付けられる、前記化合物Ｉの結晶形態を提供する。【選択図】図１