BIOMARKERS AND COMBINATION THERAPIES USING ONCOLYTIC VIRUS AND IMMUNOMODULATION

To provide a method for predicting the response of a patient having or suspected of having cancer to an oncolytic virus.SOLUTION: The method comprises the steps of (a) determining the level of expression of one or more Th1 biomarkers and/or one or more Th2 biomarkers and/or antibodies against one or...

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Bibliographische Detailangaben
Hauptverfasser:	CHARLES CONRAD, AMY HEIMBERGER, JUAN FUEYO-MARGARETO, FRANK TUFARO, FREDERICK LANG JR, ALFRED YUNG W K, CANDELARIA GOMEZ-MANZANO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	To provide a method for predicting the response of a patient having or suspected of having cancer to an oncolytic virus.SOLUTION: The method comprises the steps of (a) determining the level of expression of one or more Th1 biomarkers and/or one or more Th2 biomarkers and/or antibodies against one or more tumor associated antigens in a test sample from the patient relative to a control, and (b) comparing the level of expression to that in the control sample, where a change in the level of expression relative to the control sample is predictive of the patient's treatment response to the oncolytic virus.SELECTED DRAWING: Figure 1 【課題】癌を有するかまたは癌を有することが疑われる患者の腫瘍溶解性ウイルスに対する応答を予測する方法を提供する。【解決手段】（a）対照と比べ、患者の試験試料中の1つもしくは複数のTh1バイオマーカー、および／または1つもしくは複数のTh2バイオマーカー、および／または1つもしくは複数の腫瘍関連抗原に対する抗体の発現レベルを決定する段階、（b）該発現レベルを、対照試料中の発現レベルと比較する段階であって、対照試料と比べ、該発現レベルの変化によって、腫瘍溶解性ウイルスに対する患者の処置の応答を予測する段階。【選択図】図１