COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE

To provide compositions for treating celiac sprue.SOLUTION: The present invention provides polypeptides comprising an amino acid sequence at least 75% identical to an amino acid sequence according to SEQ ID NO:35, where (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at pH 4; (b) residu...

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Bibliographische Detailangaben
Hauptverfasser:	JUSTIN SIEGEL, SYDNEY RIN ANNA GORDON, INGRID SWANSON PULTZ, SARAH JANE WOLF, BAKER DAVID, ELIZABETH JOY STANLEY
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide compositions for treating celiac sprue.SOLUTION: The present invention provides polypeptides comprising an amino acid sequence at least 75% identical to an amino acid sequence according to SEQ ID NO:35, where (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at pH 4; (b) residue 278 is Ser, residue 78 is Glu, and residue 82 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 67 at one or more residues selected from the group consisting of 73, 102, 103, 104, 130, 165, 168, 169, 172, and 179.SELECTED DRAWING: Figure 3 【課題】セリアックスプルーを治療するための組成物を提供する。【解決手段】配列番号３５のアミノ酸配列に少なくとも７５％同一のアミノ酸配列を含んでなるポリペプチドであって、（ａ）ｐＨ４でＰＱＰＱＬＰ（配列番号３４）ペプチドを分解し；（ｂ）残基２７８はＳｅｒであり、残基７８はＧｌｕであり、残基８２はＡｓｐであり；かつ（ｃ）残基７３、１０２、１０３、１０４、１３０、１６５、１６８、１６９、１７２および１７９で構成されている群から選択された１つ以上の残基において配列番号６７と比較してアミノ酸の変更を含んでなる。【選択図】図３