ANTIBODY-DRUG CONJUGATES WITH HIGH DRUG LOADING

To provide transglutaminase-mediated antibody-drug conjugates with high antibody-drug ratio (DAR), and methods for making and using the antibody-drug conjugates.SOLUTION: The present disclosure provides antibody-drug conjugates, comprising 1) glutamine-containing tags, endogenous glutamines, and/or...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	PAVEL STROP, MAGDALENA DORYWALSKA, KATHERINE ANNE DELARIA, DAVID LOUIS SHELTON, RUSSELL GEORGE DUSHIN, DAVIDE LUCIANO FOLETTI, ARVIND RAJPAL
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!