PHARMACEUTICAL SALT FORMS OF INHIBITOR OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO)

To provide new salt forms of the SSAO inhibitor (3S)-tetrahydrofuran-3-yl(4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate having surprisingly improved properties.SOLUTION: There are provided: mesylate and sulphate salts of (3S)-tetrahydrofuran-3-yl(4S)-4-isopropyl-1,4,6,7-...

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Hauptverfasser:	EDWARD SAVORY, MICHAEL HIGGINBOTTOM
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide new salt forms of the SSAO inhibitor (3S)-tetrahydrofuran-3-yl(4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate having surprisingly improved properties.SOLUTION: There are provided: mesylate and sulphate salts of (3S)-tetrahydrofuran-3-yl(4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate mesylate, hydrates thereof, and their use in medicine.SELECTED DRAWING: None 【課題】驚くほど改善された性質を有する、ＳＳＡＯ阻害剤（３Ｓ）−テトラヒドロフラン−３−イル（４Ｓ）−４−イソプロピル−１，４，６，７−テトラヒドロ−５Ｈ−イミダゾ［４，５−ｃ］ピリジン−５−カルボキシレートの新規塩形態の提供。【解決手段】本発明は、（３Ｓ）−テトラヒドロフラン−３−イル（４Ｓ）−４−イソプロピル−１，４，６，７−テトラヒドロ−５Ｈ−イミダゾ［４，５−ｃ］ピリジン−５−カルボキシレートメシレートのメシレート塩及び硫酸塩、およびその水和物、および医薬におけるその使用を提供する。【選択図】なし