METHOD OF ANALYZING NUCLEIC ACID DERIVED FROM INDIVIDUAL CELL OR CELL POPULATION

To provide a method of analyzing a nucleic acid derived from an individual cell or a cell population.SOLUTION: There are provided a method, a composition and a system for analyzing an individual cell or a cell population through the partitioned analysis of a content of the individual cell or the cel...

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Hauptverfasser:	MICHAEL SCHNALL-LEVIN, PAUL HARDENBOL, BENJAMIN J HINDSON, MIRNA JAROSZ, PHILIP BELGRADER, ZHENG XINYING, RAJIV BHARADWAJ, KEVIN DEAN NESS HINDSON, CHRISTOPHER MARTIN HINDSON, SERGE SAXONOV
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a method of analyzing a nucleic acid derived from an individual cell or a cell population.SOLUTION: There are provided a method, a composition and a system for analyzing an individual cell or a cell population through the partitioned analysis of a content of the individual cell or the cell population. The individual cell or the cell population is co-partitioned with a processing reagent for accessing a cellular content, and for uniquely identifying the content of a given cell or cell population, and subsequently analyzing the cell's content and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of the cell's nucleic acid through sequencing.SELECTED DRAWING: Figure 9A 【課題】個々の細胞または細胞集団由来の核酸の分析方法の提供。【解決手段】個々の細胞または細胞集団の内容物の区分分析による個々の細胞または細胞集団を分析するための方法、組成物、及びシステム。個々の細胞または細胞集団は、細胞内容物にアクセスし、所定の細胞または細胞集団の内容を一意的に識別し、続いて、細胞の内容を分析して、それを個々の細胞または細胞集団に由来するものとして特徴付けるために、処理試薬と共に区分される。この分析と特徴付けには、配列決定によって細胞の核酸を分析して特徴付けることが含まれる。【選択図】図９Ａ