DOSAGE FORM INCORPORATING AMORPHOUS DRUG SOLID SOLUTION

To provide a process for producing a solid dosage form having improved bioavailability of a poorly water-soluble drug.SOLUTION: Provided is a method for making a dosage form. The method comprises: (a) preparing by melt extrusion or kneading an amorphous solid solution of one or more poorly water-sol...

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Bibliographische Detailangaben
Hauptverfasser:	MARIA DEL PILAR NORIEGA ESCOBAR, LAURA RESTREPO URIBE, CLAUDIA ANDREA SILVA BLANCO, MARCO ENRIQUE SANJUAN MEJIA, CARLOS ARTURO ALTAMAR
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	To provide a process for producing a solid dosage form having improved bioavailability of a poorly water-soluble drug.SOLUTION: Provided is a method for making a dosage form. The method comprises: (a) preparing by melt extrusion or kneading an amorphous solid solution of one or more poorly water-soluble active ingredients; and (b) placing the amorphous solid solution of the active ingredient in a suitable dosage form.SELECTED DRAWING: Figure 1 【課題】難水溶性医薬品の生物学的利用を改善した固体剤形の製造方法を提供する。【解決手段】（ａ）１種以上の難水溶性活性成分の非晶質固溶体（ａｍｏｒｐｈｏｕｓｓｏｌｉｄｓｏｌｕｔｉｏｎ）を溶融押出（ｍｅｌｔｅｘｔｒｕｓｉｏｎ）又は混練（ｋｎｅａｄｉｎｇ）して調製する工程；そして、（ｂ）前記活性成分の前記非晶質固溶体（ａｍｏｒｐｈｏｕｓｓｏｌｉｄｓｏｌｕｔｉｏｎ）を適当な剤形にする工程を含む、剤形を製造する方法である。【選択図】図１