FUNGAL STRAINS AND METHODS OF USE

To provide an improved fungal strain capable of producing altered levels of a protein, an enzyme, a variant and other substrates of interest, and use thereof.SOLUTION: An engineered fungal strain comprises a variant histidine kinase gene; the variant histidine kinase gene encodes a polypeptide compr...

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Bibliographische Detailangaben
Hauptverfasser:	ELIZABETH A BODIE, MICHAEL WARD, ROCHELLE NGUYEN, ROMAN RABINOVICH, ALEKSANDRA VIRAG, JAMES A SWEIGARD
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide an improved fungal strain capable of producing altered levels of a protein, an enzyme, a variant and other substrates of interest, and use thereof.SOLUTION: An engineered fungal strain comprises a variant histidine kinase gene; the variant histidine kinase gene encodes a polypeptide comprising an amino acid sequence comprising a mutation at a specific position of a specific sequence, and has at least 60% identity to the specific sequence.SELECTED DRAWING: Figure 1 【課題】変化したレベルの関心対象のタンパク質、酵素、変異体及び他の基質を生成することができる、改善された真菌株及びそれらの使用を提供する。【解決手段】変異ヒスチジンキナーゼ遺伝子を含み、変異ヒスチジンキナーゼ遺伝子は、特定の配列の、特定の位置での突然変異を含むアミノ酸配列を含むポリペプチドをコードし、特定の配列と少なくとも６０％の同一性を有する、組換え真菌株である。【選択図】図１