METHOD FOR PRODUCING FLUORESCEIN COMPOUND

To provide a method for producing a high-purity fluorescein compound on an industrial scale efficiently and safely.SOLUTION: A compound having a phenolic hydroxyl group and an acid anhydride are reacted with each other in the presence of an acidic catalyst, to obtain a fluorescein compound. The resultant fluorescein compound is dissolved in an alkaline solvent and then an acid is added thereto, controlling the pH of the solution into the acidic region. After that, an inorganic salt is added thereto, forming crystals. In this way, a fluorescein compound is produced.SELECTED DRAWING: Figure 1 【課題】 工業的なスケールで効率的かつ安全に、高純度のフルオレセイン類化合物を製造する方法を提供する。【解決手段】 フェノール性水酸基を有する化合物と酸無水物を、酸性触媒存在下で反応させて得られるフルオレセイン類化合物を、アルカリ性溶媒中で溶解し、次いで、酸を加えて、溶液のｐＨを酸性に調整し、その後、無機塩を添加して、結晶を析出させ、フルオレセイン類化合物を製造する。【選択図】図１