METHODS FOR TREATING, DIAGNOSING AND MONITORING RHEUMATOID ARTHRITIS

To provide a method for diagnosing a molecular subtype of rheumatoid arthritis (RA), and diagnosis, prognosis and treatment methods.SOLUTION: Four molecular subtypes of RA, namely, L subtype, M subtype, F1 subtype and F2 subtype, can be identified by measuring gene expression in a biological sample...

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Hauptverfasser:	TOWNSEND MICHAEL J, FLAVIUS MARTIN, GLYNN DENNIS JR
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a method for diagnosing a molecular subtype of rheumatoid arthritis (RA), and diagnosis, prognosis and treatment methods.SOLUTION: Four molecular subtypes of RA, namely, L subtype, M subtype, F1 subtype and F2 subtype, can be identified by measuring gene expression in a biological sample obtained from an RA subject. The present invention provides a gene expression, a protein marker and the like that are effective in identifying each of those subtypes, a method for identifying a therapeutic agent for rheumatoid arthritis effective for each subtype, and a method of predicting responsiveness to rheumatoid arthritis therapeutic agents.SELECTED DRAWING: Figure 2 【課題】関節リウマチ（ＲＡ）の分子サブタイプを診断する方法、診断方法及び予後診断方法ならびに治療方法の提供。【解決手段】ＲＡ被検者から得られた生物学的試料における遺伝子の発現を測定することにより、ＲＡをＬサブタイプ、Ｍサブタイプ、Ｆ１サブタイプ及びＦ２サブタイプの４つの分子サブタイプを同定することができる。これら各サブタイプの同定に有効な遺伝子発現マーカー及び蛋白質マーカー等の提供、各サブタイプの効果的な関節リウマチの治療薬を同定する方法、及び関節リウマチの治療薬への反応性を予測する方法の提供。【選択図】図２