4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUND

To provide novel compounds useful for treating neurological disorders including neurodegenerative disorders, especially neurological disorders characterized by the presence of oxidative stress, protein aggregation and intracellular or extracellular metal imbalance.SOLUTION: This invention relates to compounds expressed by the following formula, and metal complex compounds comprising the compounds expressed by the following formula and a transition metal compound such as zinc and copper. (R2 is (CH2) nNR9R10; R9 and R10 are each independently H, a C1-C8 alkyl optionally interrupted with O, or the like; R5 is H or the like; R6 is H, a halogen or the like; provided that one of R5 and R6 is not H; R8 is H or the like; and n is 1, 2, or 3).SELECTED DRAWING: None 【課題】神経変性障害を含む神経障害、特に、酸化ストレス、タンパク質凝集、及び細胞内又は細胞外金属不均衡の存在を特徴とする神経障害の治療に有用な新規化合物の提供。【解決手段】下記式で表される化合物、及び、下記式で表される化合物と亜鉛、銅等の遷移金属化合物とからなる金属錯体化合物。（Ｒ２は（ＣＨ２）ｎＮＲ９Ｒ１０；Ｒ９及びＲ１０は各々独立にＨ、Ｏによって場合により中断されたＣ１〜８アルキル等；Ｒ５はＨ等；Ｒ６は、Ｈ、ハロゲン等；ただし、Ｒ５およびＲ６のうちの１つがＨではない；Ｒ８はＨ等；ｎは１、２又は３。）【選択図】なし