BENZO HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION

To provide a pharmaceutical composition for treating or preventing cancer related to PD-L1, septic fever or sepsis shock.SOLUTION: There is provided a pharmaceutical composition including benzoxazole derivative expressed by a formula (I), and the composition is preferably administered in combination...

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Bibliographische Detailangaben
Hauptverfasser:	CHANG CHIA-MING, WEI TSAI-YIN, LU YEN-TA, SHIH TZENGE-LIEN, LIU JEN-WEI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide a pharmaceutical composition for treating or preventing cancer related to PD-L1, septic fever or sepsis shock.SOLUTION: There is provided a pharmaceutical composition including benzoxazole derivative expressed by a formula (I), and the composition is preferably administered in combination with other anticancer agent, or an immunity check point inhibitor such as an anti PD-L1 antibody, an anti PD-1 antibody, an anti CTLA-4 antibody.SELECTED DRAWING: Figure 3 【課題】ＰＤ−Ｌ１関連のがん、敗血症もしくは敗血症性ショックを治療又は予防するための医薬組成物の提供。【解決手段】式（Ｉ）で代表されるベンゾオキサゾール誘導体を含む医薬組成物。他の抗がん剤、又は、抗ＰＤ−Ｌ１抗体、抗ＰＤ−１抗体、抗ＣＴＬＡ−４抗体等の免疫チェックポイント阻害剤と組み合わせて投与されることが好ましい。【選択図】図３