REAGENT AND METHOD FOR IDENTIFYING, CONDENSING AND/OR GROWING ANTIGEN SPECIFIC T CELL

To provide a quick condensation method and growth method of an antigen specific T cell for more efficient immune therapy by using adoptive transfer.SOLUTION: There is provided a method for preparing an antigen specific T cell, comprising a step for bringing a sample including a T cell derived from a...

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Bibliographische Detailangaben
Hauptverfasser:	MATHIAS OELKE, JOAN GLICK BIELER, JONATHAN SCHNECK, KARLO PERICA
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a quick condensation method and growth method of an antigen specific T cell for more efficient immune therapy by using adoptive transfer.SOLUTION: There is provided a method for preparing an antigen specific T cell, comprising a step for bringing a sample including a T cell derived from a patient or a proper doner into contact with a particle mass (nano-scale artificial antigen presentation cell) including paramagnetism and including on a surface, MHC-peptide antigen presentation composite, and collecting and condensing the antigen specific T cell associated with the particle mass, and a step for growing the antigen specific T cells.SELECTED DRAWING: Figure 1 【課題】養子移入によるより有効な免疫療法のための、抗原特異的Ｔ細胞の迅速な濃縮及び増殖方法の提供。【解決手段】抗原特異的Ｔ細胞集団を調製するための方法であって、患者または適切なドナー由来のＴ細胞を含む試料を常磁性でありかつ表面上にＭＨＣ−ペプチド抗原提示複合体を含む粒子集団（ナノスケール人工的抗原提示細胞）と接触させ、該粒子集団と会合した抗原特異的Ｔ細胞を回収、濃縮する段階と、該抗原特異的Ｔ細胞を増殖させる段階とを含む方法。【選択図】図１