MONOSUBSTITUTED OR POLYSUBSTITUTED AMPHIPHILIC HYPOCRELLIN DERIVATIVE, AND USE THEREOF

To provide a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and use of the derivative for production of a photosensitizer drug for photodynamic therapy.SOLUTION: The amphiphilic hypocrellin derivative is represented by the formula (I) in the figure. In the formula (I), R1 represents -H or -COCH3, and R represents a substituent that may have various linking groups, where a terminal group of the R has hydrogen, an alkyl group, an alkoxy group, a phenyl group, a heterocycle, a hydroxy group, a mercapto group, a carboxyl group, a sulfo group, or a substituted pyridyl group in which a nitrogen atom is quaternized and positively charged.SELECTED DRAWING: Figure 1 【課題】一置換又は多置換の油水両親媒性ヒポクレリン誘導体、及び光線力学的治療用の光増感薬を製造するための前記誘導体の使用を提供する。【解決手段】式（Ｉ）で表される油水両親媒性ヒポクレリン誘導体。式（Ｉ）中、Ｒ１は−Ｈ又は−ＣＯＣＨ３、Ｒは種々の連結基を有していてもよい置換基を表し、前記Ｒの末端基は、水素、アルキル基、アルコキシ基、フェニル基、複素環、ヒドロキシ基、メルカプト基、カルボキシル基、スルホ基又は窒素原子が四級化して正電荷を帯びた置換ピリジル基を有する置換基を表す。【選択図】図１