METHOD FOR DETERMINING OCCURRENCE OF INVASIVE ADENOCARCINOMA, METHOD FOR ANALYSIS THEREFOR, AND MARKER GLYCOPROTEIN AND FRAGMENT THEREOF FOR USE IN THESE METHODS

To provide marker glycoproteins or fragment thereof for accurately determining whether the pulmonary adenocarcinoma of a subject is invasive adenocarcinoma or not by discriminating it from preinvasive lesion or microinvasive carcinoma, as well as methods for determining occurrence of invasive adenoc...

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Hauptverfasser:	MAEDA JUNICHI, KUNO ATSUSHI, NOGUCHI MASAYUKI, TOGAYANAI AKIRA, KAJI HIROYUKI, IKEDA NORIHIKO, SAKURAI YASUO, NARIMATSU HISASHI, KANAYAMA SHOICHI, NAGAO TOSHITAKA, MATSUOKA RYOTA, YOSHIMURA SAIKO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide marker glycoproteins or fragment thereof for accurately determining whether the pulmonary adenocarcinoma of a subject is invasive adenocarcinoma or not by discriminating it from preinvasive lesion or microinvasive carcinoma, as well as methods for determining occurrence of invasive adenocarcinoma and analysis methods.SOLUTION: A marker glycoprotein according to an embodiment determines whether the type of adenocarcinoma affecting a subject is invasive adenocarcinoma or not by discriminating it from preinvasive lesion or microinvasive carcinoma. The marker glycoprotein comprises a protein and a sugar chain bonded to the protein. The protein is PLOD3 or CP, and the sugar chain is capable of binding to HHL.SELECTED DRAWING: Figure 1 【課題】本発明が解決しようとする課題は、対象が罹患している肺腺癌の分類が浸潤性腺癌であるか否かを、前浸潤性病変又は微小浸潤性癌と区別して正確に識別するためのマーカー糖タンパク質マーカー糖タンパク質、その断片、浸潤性腺癌罹患判定方法及び分析方法を提供することである。【解決手段】実施形態に従うマーカー糖タンパク質は、対象が罹患している肺腺癌の分類が浸潤性腺癌であるか否かを、前浸潤性病変又は微小浸潤性癌と区別して識別するためのマーカー糖タンパク質である。マーカー糖タンパク質は、タンパク質及び当該タンパク質に結合している糖鎖を含む。タンパク質はＰＬＯＤ３又はＣＰであり、糖鎖はＨＨＬに対して結合能を有する。【選択図】図１