[6R]-MTHF MULTIPLE-BOLUS ADMINISTRATION IN 5-FLUOROURACIL CHEMOTHERAPY

To provide treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC).SOLUTION: The present invention relates to treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering multiple boluses of diastereomerically pur...

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Hauptverfasser:	ANDERS VEDIN, PER LENNART LINDBERG, GUNNEL ELISABET SUNDEN, GUSTAVSSON BENGT
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC).SOLUTION: The present invention relates to treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering multiple boluses of diastereomerically pure folate adjuvant [6R]-5,10-methylenetetrahydrofolate in 5-fluorouracil (5-FU) based chemotherapy.SELECTED DRAWING: Figure 2 【課題】癌などのヒトにおける固形腫瘍、特に結腸直腸癌（ＣＲＣ）、の治療に関する。【解決手段】本発明は、５−フルオロウラシル（５−ＦＵ）を使用した化学療法における、ジアステレオマー的に純粋な葉酸アジュバント［６Ｒ］−５，１０−メチレンテトラヒドロ葉酸の複数回ボーラス投与を伴うことによる、癌などのヒトにおける固形腫瘍、特に結腸直腸癌（ＣＲＣ）、の治療に関する。【選択図】図２