POLYPEPTIDE HAVING CELL-PERMEABLE SEQUENCE, AND COMPOSITION CONTAINING THE SAME
To provide polypeptides having a safe and efficient cell-permeable sequence.SOLUTION: Provided is a polypeptide represented by the following formula (I), [where, n is a number from 2 to 20; R1 and R2 may independently represent alkyl groups C1 to C4, or may be bonded to each other to form a ring; R3...
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| creator | MIYAMOTO TAKAAKI NUMATA KEIJI TSUCHIYA KOSUKE MIYAGI YU |
| description | To provide polypeptides having a safe and efficient cell-permeable sequence.SOLUTION: Provided is a polypeptide represented by the following formula (I), [where, n is a number from 2 to 20; R1 and R2 may independently represent alkyl groups C1 to C4, or may be bonded to each other to form a ring; R3 represents the primary amino alkyl groups of C1 to C10; R4 represents a hydrogen atom or a hydrocarbon group of C1-10; n pieces of R1, R2, R3 and R4 in the formula may be the same or different from each other; and the N-terminus and C-terminus may be modified or unmodified, respectively].SELECTED DRAWING: Figure 4
【課題】安全でかつ効率のよい細胞透過性配列を有するポリペプチドの提供。【解決手段】下記式（Ｉ）：［式中、ｎは２〜２０の数であり；Ｒ１及びＲ２は、それぞれ独立して、Ｃ１〜Ｃ４のアルキル基を表すか、又は互いに結合して環を形成してもよく；Ｒ３は、Ｃ１〜Ｃ１０の第一級アミノアルキル基を表し；Ｒ４は、水素原子、又はＣ１〜１０の炭化水素基を表し；式中のｎ個のＲ１、Ｒ２、Ｒ３及びＲ４は、各々、互いに同一でも異なっていてもよく；並びに、Ｎ末端及びＣ末端はそれぞれ、修飾されていてもよいし、又は非修飾であってもよい。］で表されるポリペプチド。【選択図】図４ |
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【課題】安全でかつ効率のよい細胞透過性配列を有するポリペプチドの提供。【解決手段】下記式（Ｉ）：［式中、ｎは２〜２０の数であり；Ｒ１及びＲ２は、それぞれ独立して、Ｃ１〜Ｃ４のアルキル基を表すか、又は互いに結合して環を形成してもよく；Ｒ３は、Ｃ１〜Ｃ１０の第一級アミノアルキル基を表し；Ｒ４は、水素原子、又はＣ１〜１０の炭化水素基を表し；式中のｎ個のＲ１、Ｒ２、Ｒ３及びＲ４は、各々、互いに同一でも異なっていてもよく；並びに、Ｎ末端及びＣ末端はそれぞれ、修飾されていてもよいし、又は非修飾であってもよい。］で表されるポリペプチド。【選択図】図４</description><language>eng ; jpn</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201008&DB=EPODOC&CC=JP&NR=2020164496A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201008&DB=EPODOC&CC=JP&NR=2020164496A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MIYAMOTO TAKAAKI</creatorcontrib><creatorcontrib>NUMATA KEIJI</creatorcontrib><creatorcontrib>TSUCHIYA KOSUKE</creatorcontrib><creatorcontrib>MIYAGI YU</creatorcontrib><title>POLYPEPTIDE HAVING CELL-PERMEABLE SEQUENCE, AND COMPOSITION CONTAINING THE SAME</title><description>To provide polypeptides having a safe and efficient cell-permeable sequence.SOLUTION: Provided is a polypeptide represented by the following formula (I), [where, n is a number from 2 to 20; R1 and R2 may independently represent alkyl groups C1 to C4, or may be bonded to each other to form a ring; R3 represents the primary amino alkyl groups of C1 to C10; R4 represents a hydrogen atom or a hydrocarbon group of C1-10; n pieces of R1, R2, R3 and R4 in the formula may be the same or different from each other; and the N-terminus and C-terminus may be modified or unmodified, respectively].SELECTED DRAWING: Figure 4
【課題】安全でかつ効率のよい細胞透過性配列を有するポリペプチドの提供。【解決手段】下記式（Ｉ）：［式中、ｎは２〜２０の数であり；Ｒ１及びＲ２は、それぞれ独立して、Ｃ１〜Ｃ４のアルキル基を表すか、又は互いに結合して環を形成してもよく；Ｒ３は、Ｃ１〜Ｃ１０の第一級アミノアルキル基を表し；Ｒ４は、水素原子、又はＣ１〜１０の炭化水素基を表し；式中のｎ個のＲ１、Ｒ２、Ｒ３及びＲ４は、各々、互いに同一でも異なっていてもよく；並びに、Ｎ末端及びＣ末端はそれぞれ、修飾されていてもよいし、又は非修飾であってもよい。］で表されるポリペプチド。【選択図】図４</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAP8PeJDHANCPF0cVXwcAzz9HNXcHb18dENcA3ydXV08nFVCHYNDHX1c3bVUXD0c1Fw9vcN8A_2DPH09wOy_UIcPf1AekI8gAodfV15GFjTEnOKU3mhNDeDkptriLOHbmpBfnxqcUFicmpeakm8V4CRgZGBoZmJiaWZozFRigCj4C8x</recordid><startdate>20201008</startdate><enddate>20201008</enddate><creator>MIYAMOTO TAKAAKI</creator><creator>NUMATA KEIJI</creator><creator>TSUCHIYA KOSUKE</creator><creator>MIYAGI YU</creator><scope>EVB</scope></search><sort><creationdate>20201008</creationdate><title>POLYPEPTIDE HAVING CELL-PERMEABLE SEQUENCE, AND COMPOSITION CONTAINING THE SAME</title><author>MIYAMOTO TAKAAKI ; NUMATA KEIJI ; TSUCHIYA KOSUKE ; MIYAGI YU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2020164496A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>MIYAMOTO TAKAAKI</creatorcontrib><creatorcontrib>NUMATA KEIJI</creatorcontrib><creatorcontrib>TSUCHIYA KOSUKE</creatorcontrib><creatorcontrib>MIYAGI YU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MIYAMOTO TAKAAKI</au><au>NUMATA KEIJI</au><au>TSUCHIYA KOSUKE</au><au>MIYAGI YU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>POLYPEPTIDE HAVING CELL-PERMEABLE SEQUENCE, AND COMPOSITION CONTAINING THE SAME</title><date>2020-10-08</date><risdate>2020</risdate><abstract>To provide polypeptides having a safe and efficient cell-permeable sequence.SOLUTION: Provided is a polypeptide represented by the following formula (I), [where, n is a number from 2 to 20; R1 and R2 may independently represent alkyl groups C1 to C4, or may be bonded to each other to form a ring; R3 represents the primary amino alkyl groups of C1 to C10; R4 represents a hydrogen atom or a hydrocarbon group of C1-10; n pieces of R1, R2, R3 and R4 in the formula may be the same or different from each other; and the N-terminus and C-terminus may be modified or unmodified, respectively].SELECTED DRAWING: Figure 4
【課題】安全でかつ効率のよい細胞透過性配列を有するポリペプチドの提供。【解決手段】下記式（Ｉ）：［式中、ｎは２〜２０の数であり；Ｒ１及びＲ２は、それぞれ独立して、Ｃ１〜Ｃ４のアルキル基を表すか、又は互いに結合して環を形成してもよく；Ｒ３は、Ｃ１〜Ｃ１０の第一級アミノアルキル基を表し；Ｒ４は、水素原子、又はＣ１〜１０の炭化水素基を表し；式中のｎ個のＲ１、Ｒ２、Ｒ３及びＲ４は、各々、互いに同一でも異なっていてもよく；並びに、Ｎ末端及びＣ末端はそれぞれ、修飾されていてもよいし、又は非修飾であってもよい。］で表されるポリペプチド。【選択図】図４</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | POLYPEPTIDE HAVING CELL-PERMEABLE SEQUENCE, AND COMPOSITION CONTAINING THE SAME |
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