POLYPEPTIDE HAVING CELL-PERMEABLE SEQUENCE, AND COMPOSITION CONTAINING THE SAME

To provide polypeptides having a safe and efficient cell-permeable sequence.SOLUTION: Provided is a polypeptide represented by the following formula (I), [where, n is a number from 2 to 20; R1 and R2 may independently represent alkyl groups C1 to C4, or may be bonded to each other to form a ring; R3...

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Hauptverfasser: MIYAMOTO TAKAAKI, NUMATA KEIJI, TSUCHIYA KOSUKE, MIYAGI YU
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:To provide polypeptides having a safe and efficient cell-permeable sequence.SOLUTION: Provided is a polypeptide represented by the following formula (I), [where, n is a number from 2 to 20; R1 and R2 may independently represent alkyl groups C1 to C4, or may be bonded to each other to form a ring; R3 represents the primary amino alkyl groups of C1 to C10; R4 represents a hydrogen atom or a hydrocarbon group of C1-10; n pieces of R1, R2, R3 and R4 in the formula may be the same or different from each other; and the N-terminus and C-terminus may be modified or unmodified, respectively].SELECTED DRAWING: Figure 4 【課題】安全でかつ効率のよい細胞透過性配列を有するポリペプチドの提供。【解決手段】下記式(I):[式中、nは2〜20の数であり;R1及びR2は、それぞれ独立して、C1〜C4のアルキル基を表すか、又は互いに結合して環を形成してもよく;R3は、C1〜C10の第一級アミノアルキル基を表し;R4は、水素原子、又はC1〜10の炭化水素基を表し;式中のn個のR1、R2、R3及びR4は、各々、互いに同一でも異なっていてもよく;並びに、N末端及びC末端はそれぞれ、修飾されていてもよいし、又は非修飾であってもよい。]で表されるポリペプチド。【選択図】図4