RISK ASSESSMENT METHOD FOR NON-ALCOHOLIC LIVER DISEASE USING SINGLE NUCLEOTIDE POLYMORPHISM

To provide methods for predicting the risk of developing NAFLD, NASH, and NASH-HCC, and to provide reagents for predicting the same.SOLUTION: Provided is a method and the like for predicting the risk of developing NAFLD in a subject (healthy person), the method comprising detecting in the sample from the subject the following single nucleotide polymorphisms: (1) the 27730940th single nucleotide polymorphism of the GCKR gene on human chromosome 2, or a single nucleotide polymorphism in linkage disequilibrium with the single nucleotide polymorphism; (2) the 44333694th single nucleotide polymorphism of PNPLA3 gene on human chromosome 22, or a single nucleotide polymorphism in linkage disequilibrium with the single nucleotide polymorphism; and (3) the 19545099th single nucleotide polymorphism of GATAD2A gene on human chromosome 19, or a single nucleotide polymorphism in linkage disequilibrium with the single nucleotide polymorphism.SELECTED DRAWING: None 【課題】NAFLD、NASH、及びNASH-HCC発症のリスクを予測するための方法及び予測用試薬等を提供する。【解決手段】対象（健常者）におけるNAFLD発症のリスクを予測するための方法であって、前記対象由来の試料中の以下：（1）ヒト第2染色体上のGCKR遺伝子の第27730940番目の一塩基多型、又は前記一塩基多型と連鎖不平衡状態にある一塩基多型、（2）ヒト第22染色体上のPNPLA3遺伝子の第44333694番目の一塩基多型、又は前記一塩基多型と連鎖不平衡状態にある一塩基多型、及び（3）ヒト第19染色体上のGATAD2A遺伝子の第19545099番目の一塩基多型、又は前記一塩基多型と連鎖不平衡状態にある一塩基多型を検出することを含む、方法等。【選択図】なし