PRODUCTION METHOD OF 14-BROMO ANTHRACYCLINE
To provide safe and efficient production methods of 14-bromo anthracycline.SOLUTION: A production method of 14-bromo anthracycline, according to the following reaction scheme, comprises the steps of performing ketalization of 13-carbonyl, 14-bromination by an N-bromo compound, and deketalization, th...
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| creator | OHARA KEIICHIRO KANDA YASUHISA ARAUCHI HARUTO YOSHIDA NAOTO |
| description | To provide safe and efficient production methods of 14-bromo anthracycline.SOLUTION: A production method of 14-bromo anthracycline, according to the following reaction scheme, comprises the steps of performing ketalization of 13-carbonyl, 14-bromination by an N-bromo compound, and deketalization, these steps being performed in one pot. The method can produce 14-bromo anthracycline without using bromine which requires careful handling, and without a powder handling step.SELECTED DRAWING: None
【課題】１４−ブロモアンスラサイクリンの、安全かつ効率のよい製造方法の提供。【解決手段】次の反応スキームに従い、１３−カルボニルのケタール化、Ｎ−ブロモ化合物による１４位ブロモ化、脱ケタール化工程を含み、これらの工程をワンポットで実施する１４−ブロモアンスラサイクリンの製造方法。取扱いに注意を要する臭素を用いることなく、また粉体取扱い工程を経ずに１４−ブロモアンスラサイクリンを製造することができる。【選択図】なし |
| format | Patent |
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【課題】１４−ブロモアンスラサイクリンの、安全かつ効率のよい製造方法の提供。【解決手段】次の反応スキームに従い、１３−カルボニルのケタール化、Ｎ−ブロモ化合物による１４位ブロモ化、脱ケタール化工程を含み、これらの工程をワンポットで実施する１４−ブロモアンスラサイクリンの製造方法。取扱いに注意を要する臭素を用いることなく、また粉体取扱い工程を経ずに１４−ブロモアンスラサイクリンを製造することができる。【選択図】なし</description><language>eng ; jpn</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SUGARS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200806&DB=EPODOC&CC=JP&NR=2020117468A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200806&DB=EPODOC&CC=JP&NR=2020117468A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OHARA KEIICHIRO</creatorcontrib><creatorcontrib>KANDA YASUHISA</creatorcontrib><creatorcontrib>ARAUCHI HARUTO</creatorcontrib><creatorcontrib>YOSHIDA NAOTO</creatorcontrib><title>PRODUCTION METHOD OF 14-BROMO ANTHRACYCLINE</title><description>To provide safe and efficient production methods of 14-bromo anthracycline.SOLUTION: A production method of 14-bromo anthracycline, according to the following reaction scheme, comprises the steps of performing ketalization of 13-carbonyl, 14-bromination by an N-bromo compound, and deketalization, these steps being performed in one pot. The method can produce 14-bromo anthracycline without using bromine which requires careful handling, and without a powder handling step.SELECTED DRAWING: None
【課題】１４−ブロモアンスラサイクリンの、安全かつ効率のよい製造方法の提供。【解決手段】次の反応スキームに従い、１３−カルボニルのケタール化、Ｎ−ブロモ化合物による１４位ブロモ化、脱ケタール化工程を含み、これらの工程をワンポットで実施する１４−ブロモアンスラサイクリンの製造方法。取扱いに注意を要する臭素を用いることなく、また粉体取扱い工程を経ずに１４−ブロモアンスラサイクリンを製造することができる。【選択図】なし</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAOCPJ3CXUO8fT3U_B1DfHwd1Hwd1MwNNF1CvL39Vdw9AvxCHJ0jnT28fRz5WFgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8V4BRgZGBoaG5iZmFo7GRCkCAK8mJTc</recordid><startdate>20200806</startdate><enddate>20200806</enddate><creator>OHARA KEIICHIRO</creator><creator>KANDA YASUHISA</creator><creator>ARAUCHI HARUTO</creator><creator>YOSHIDA NAOTO</creator><scope>EVB</scope></search><sort><creationdate>20200806</creationdate><title>PRODUCTION METHOD OF 14-BROMO ANTHRACYCLINE</title><author>OHARA KEIICHIRO ; KANDA YASUHISA ; ARAUCHI HARUTO ; YOSHIDA NAOTO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2020117468A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>OHARA KEIICHIRO</creatorcontrib><creatorcontrib>KANDA YASUHISA</creatorcontrib><creatorcontrib>ARAUCHI HARUTO</creatorcontrib><creatorcontrib>YOSHIDA NAOTO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OHARA KEIICHIRO</au><au>KANDA YASUHISA</au><au>ARAUCHI HARUTO</au><au>YOSHIDA NAOTO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODUCTION METHOD OF 14-BROMO ANTHRACYCLINE</title><date>2020-08-06</date><risdate>2020</risdate><abstract>To provide safe and efficient production methods of 14-bromo anthracycline.SOLUTION: A production method of 14-bromo anthracycline, according to the following reaction scheme, comprises the steps of performing ketalization of 13-carbonyl, 14-bromination by an N-bromo compound, and deketalization, these steps being performed in one pot. The method can produce 14-bromo anthracycline without using bromine which requires careful handling, and without a powder handling step.SELECTED DRAWING: None
【課題】１４−ブロモアンスラサイクリンの、安全かつ効率のよい製造方法の提供。【解決手段】次の反応スキームに従い、１３−カルボニルのケタール化、Ｎ−ブロモ化合物による１４位ブロモ化、脱ケタール化工程を含み、これらの工程をワンポットで実施する１４−ブロモアンスラサイクリンの製造方法。取扱いに注意を要する臭素を用いることなく、また粉体取扱い工程を経ずに１４−ブロモアンスラサイクリンを製造することができる。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS |
| title | PRODUCTION METHOD OF 14-BROMO ANTHRACYCLINE |
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