SODIUM(2R,5S,13aR)-7,9-DIOXO-10-((2,4,6-TRIFLUOROBENZYL)CARBAMOYL)-2,3,4,5,7,9,13,13a-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZEPIN-8-OLATE

SODIUM(2R,5S,13aR)-7,9-DIOXO-10-((2,4,6-TRIFLUOROBENZYL)CARBAMOYL)-2,3,4,5,7,9,13,13a-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZEPIN-8-OLATE

To provide antiretroviral therapies having a decreased potential for drug interactions.SOLUTION: There are provided sodium (2R,5S,13aR)-7,9-dioxo-10 -((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5] pyrazino[2,1-b][1,3]oxazepin-8-olate Form I hav...

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Hauptverfasser: IRENE CHEN, ERNEST A CARRA, VAHID ZIA
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:To provide antiretroviral therapies having a decreased potential for drug interactions.SOLUTION: There are provided sodium (2R,5S,13aR)-7,9-dioxo-10 -((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5] pyrazino[2,1-b][1,3]oxazepin-8-olate Form I having a structure represented by following formula (II), the crystalline forms, the pharmaceutical formulations, and the therapeutic uses thereof.SELECTED DRAWING: Figure 1 【課題】薬物相互作用についての可能性を低下させる抗レトロウイルス剤療法を提供する。【解決手段】下式（ＩＩ）の構造を有する、ナトリウム（２Ｒ，５Ｓ，１３ａＲ）−７，９−ジオキソ−１０−（（２，４，６−トリフルオロベンジル）カルバモイル）−２，３，４，５，７，９，１３，１３ａ−オクタヒドロ−２，５−メタノピリド［１'，２'：４，５］ピラジノ［２，１−ｂ］［１，３］オキサゼピン−８−オレートＩ型、それらの結晶形、それらの医薬製剤、およびそれらの治療的使用。【選択図】図１