FOREIGN SUGAR CHAIN MODIFIED MEMBRANE VEHICLE USING USEFUL COLIFORM DOUBLE VARIANT
To provide MW of Gram negative bacteria on which pneumococcus capsule polysaccharide is mounted.SOLUTION: There is provided MV of Gram negative bacteria, in which lipopolysaccharide being a component of an outer membrane comprises lipid A, core oligosaccharide, and pneumococcus capsule polysaccharid...
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| creator | NAKAO RYUMA HIRAYAMA SATORU |
| description | To provide MW of Gram negative bacteria on which pneumococcus capsule polysaccharide is mounted.SOLUTION: There is provided MV of Gram negative bacteria, in which lipopolysaccharide being a component of an outer membrane comprises lipid A, core oligosaccharide, and pneumococcus capsule polysaccharide. The Gram negative bacteria are coliform Nissle 1917 strains. The MV is separated from a coliform double variant with gene mutation which is ΔflhD and ΔwbbL. By intranasal administration of a vaccine including the MV for transporting the pneumococcus capsule polysaccharide, an antibody to pneumococcus can be produced and guided to each portion of blood, a nasal cavity, an oral cavity and a lung.SELECTED DRAWING: Figure 1
【課題】肺炎球菌莢膜ポリサッカライドを載せたグラム陰性菌のMVを提供する。【解決手段】グラム陰性菌のMVであって、外膜の構成部分であるリポ多糖が、リピドＡと、コアオリゴ糖と、肺炎球菌莢膜ポリサッカライドを有する。グラム陰性菌は大腸菌Nissle 1917株である。このMVは、ΔflhD及びΔwbbLである遺伝子変異を有する大腸菌二重変異株から単離される。この肺炎球菌莢膜多糖を運ぶMVを含むワクチンの鼻腔内投与により、血中、鼻腔、口腔及び肺の各部位に、肺炎球菌に対する抗体を産生誘導できる。【選択図】図１ |
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【課題】肺炎球菌莢膜ポリサッカライドを載せたグラム陰性菌のMVを提供する。【解決手段】グラム陰性菌のMVであって、外膜の構成部分であるリポ多糖が、リピドＡと、コアオリゴ糖と、肺炎球菌莢膜ポリサッカライドを有する。グラム陰性菌は大腸菌Nissle 1917株である。このMVは、ΔflhD及びΔwbbLである遺伝子変異を有する大腸菌二重変異株から単離される。この肺炎球菌莢膜多糖を運ぶMVを含むワクチンの鼻腔内投与により、血中、鼻腔、口腔及び肺の各部位に、肺炎球菌に対する抗体を産生誘導できる。【選択図】図１</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES ; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NANOTECHNOLOGY ; PERFORMING OPERATIONS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES ; SPIRITS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200611&DB=EPODOC&CC=JP&NR=2020089292A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200611&DB=EPODOC&CC=JP&NR=2020089292A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NAKAO RYUMA</creatorcontrib><creatorcontrib>HIRAYAMA SATORU</creatorcontrib><title>FOREIGN SUGAR CHAIN MODIFIED MEMBRANE VEHICLE USING USEFUL COLIFORM DOUBLE VARIANT</title><description>To provide MW of Gram negative bacteria on which pneumococcus capsule polysaccharide is mounted.SOLUTION: There is provided MV of Gram negative bacteria, in which lipopolysaccharide being a component of an outer membrane comprises lipid A, core oligosaccharide, and pneumococcus capsule polysaccharide. The Gram negative bacteria are coliform Nissle 1917 strains. The MV is separated from a coliform double variant with gene mutation which is ΔflhD and ΔwbbL. By intranasal administration of a vaccine including the MV for transporting the pneumococcus capsule polysaccharide, an antibody to pneumococcus can be produced and guided to each portion of blood, a nasal cavity, an oral cavity and a lung.SELECTED DRAWING: Figure 1
【課題】肺炎球菌莢膜ポリサッカライドを載せたグラム陰性菌のMVを提供する。【解決手段】グラム陰性菌のMVであって、外膜の構成部分であるリポ多糖が、リピドＡと、コアオリゴ糖と、肺炎球菌莢膜ポリサッカライドを有する。グラム陰性菌は大腸菌Nissle 1917株である。このMVは、ΔflhD及びΔwbbLである遺伝子変異を有する大腸菌二重変異株から単離される。この肺炎球菌莢膜多糖を運ぶMVを含むワクチンの鼻腔内投与により、血中、鼻腔、口腔及び肺の各部位に、肺炎球菌に対する抗体を産生誘導できる。【選択図】図１</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MANUFACTURE OR TREATMENT OF NANOSTRUCTURES</subject><subject>MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NANOTECHNOLOGY</subject><subject>PERFORMING OPERATIONS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES</subject><subject>SPIRITS</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi70KwjAURrs4iPoOF3chxMWOaXKTXMmPpE3XUiROooX6_pjBB3D5znDOt22SjgnJBOizEQmkFRTAR0WaUIFH3yUREEa0JB1C7imYuqizAxkd1bsHFXNX5SgSiTDsm81jfq7l8OOuOWocpD2V5T2VdZnv5VU-0_XGGWfs0vKWi_Nf0RcZey_t</recordid><startdate>20200611</startdate><enddate>20200611</enddate><creator>NAKAO RYUMA</creator><creator>HIRAYAMA SATORU</creator><scope>EVB</scope></search><sort><creationdate>20200611</creationdate><title>FOREIGN SUGAR CHAIN MODIFIED MEMBRANE VEHICLE USING USEFUL COLIFORM DOUBLE VARIANT</title><author>NAKAO RYUMA ; HIRAYAMA SATORU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2020089292A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MANUFACTURE OR TREATMENT OF NANOSTRUCTURES</topic><topic>MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NANOTECHNOLOGY</topic><topic>PERFORMING OPERATIONS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES</topic><topic>SPIRITS</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>NAKAO RYUMA</creatorcontrib><creatorcontrib>HIRAYAMA SATORU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NAKAO RYUMA</au><au>HIRAYAMA SATORU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FOREIGN SUGAR CHAIN MODIFIED MEMBRANE VEHICLE USING USEFUL COLIFORM DOUBLE VARIANT</title><date>2020-06-11</date><risdate>2020</risdate><abstract>To provide MW of Gram negative bacteria on which pneumococcus capsule polysaccharide is mounted.SOLUTION: There is provided MV of Gram negative bacteria, in which lipopolysaccharide being a component of an outer membrane comprises lipid A, core oligosaccharide, and pneumococcus capsule polysaccharide. The Gram negative bacteria are coliform Nissle 1917 strains. The MV is separated from a coliform double variant with gene mutation which is ΔflhD and ΔwbbL. By intranasal administration of a vaccine including the MV for transporting the pneumococcus capsule polysaccharide, an antibody to pneumococcus can be produced and guided to each portion of blood, a nasal cavity, an oral cavity and a lung.SELECTED DRAWING: Figure 1
【課題】肺炎球菌莢膜ポリサッカライドを載せたグラム陰性菌のMVを提供する。【解決手段】グラム陰性菌のMVであって、外膜の構成部分であるリポ多糖が、リピドＡと、コアオリゴ糖と、肺炎球菌莢膜ポリサッカライドを有する。グラム陰性菌は大腸菌Nissle 1917株である。このMVは、ΔflhD及びΔwbbLである遺伝子変異を有する大腸菌二重変異株から単離される。この肺炎球菌莢膜多糖を運ぶMVを含むワクチンの鼻腔内投与により、血中、鼻腔、口腔及び肺の各部位に、肺炎球菌に対する抗体を産生誘導できる。【選択図】図１</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SPIRITS TRANSPORTING VINEGAR WINE |
| title | FOREIGN SUGAR CHAIN MODIFIED MEMBRANE VEHICLE USING USEFUL COLIFORM DOUBLE VARIANT |
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