HYDROGEL COMPOSITIONS FOR USE IN PROMOTING TUBULOGENESIS

To provide hydrogel compositions and to provide methods of using hydrogel compositions.SOLUTION: Provided is a method of screening for pro-tubulogenic agents and anti-tubulogenic agents, the method comprising: producing a hydrogel composition, in which the hydrogel composition comprises a polyethyle...

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Bibliographische Detailangaben
Hauptverfasser:	ERIC HUY DANG NGUYEN, MICHAEL P SCHWARTZ, DAVID GREGORY BELAIR, LE NGOC NHI, STEFAN ZORN, MATTHEW BRIAN PARLATO, HAMISHA ARDALANI, WILLIAM L MURPHY, MATTHEW ZANOTELLI, WILLIAM T DALY
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide hydrogel compositions and to provide methods of using hydrogel compositions.SOLUTION: Provided is a method of screening for pro-tubulogenic agents and anti-tubulogenic agents, the method comprising: producing a hydrogel composition, in which the hydrogel composition comprises a polyethylene glycol functionalized with norbornene, a crosslinking peptide, a cell adhesion peptide, and a soluble factor binder; providing an agent considered to promote or reduce tubulogenesis; contacting a cell with the hydrogel composition and the agent; and analyzing the cell.SELECTED DRAWING: None 【課題】ヒドロゲル組成物およびヒドロゲル組成物の使用方法を開示する。【解決手段】細管形成促進剤および抗細管形成剤のスクリーニング方法であって、ヒドロゲル組成物(ここで、ヒドロゲル組成物は、ノルボルネンで官能化されたポリエチレングリコール、架橋ペプチド、細胞接着ペプチドおよび可溶性因子結合剤を含む)を製造すること；細管形成を促進または減少させると思われる作用剤を提供すること；細胞を、ヒドロゲル組成物および作用剤に接触させること；および細胞を分析すること；を含む方法。【選択図】なし