ANTI-GP73 MONOCLONAL ANTIBODIES AND METHODS OF OBTAINING THE SAME

To provide anti-GP73 monoclonal antibodies that are sensitive to the presence or absence of the fucose sugar moiety on GP73 molecule and capable of binding to the fucosylated form of GP73, or that are not sensitive to the presence or absence of the fucose sugar moiety on GP73 molecule, but have suff...

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Hauptverfasser:	ANTHONY S MUERHOFF, TU BAILIN, DAVID J HAWKSWORTH, ROBERT N ZIEMANN, CAROL S RAMSAY, PHILIP M HEMKEN, BRYAN C TIEMAN, SUSAN E BROPHY, ZHAO CHENG, BARRY L DOWELL, CAROLYN J STROBEL, LARRY G BIRKENMEYER
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide anti-GP73 monoclonal antibodies that are sensitive to the presence or absence of the fucose sugar moiety on GP73 molecule and capable of binding to the fucosylated form of GP73, or that are not sensitive to the presence or absence of the fucose sugar moiety on GP73 molecule, but have sufficient binding affinity for use in an immunoassay to detect GP73 and/or fucosylated GP73.SOLUTION: Provided is an isolated antibody or antibody fragment thereof capable of binding an epitope within the amino acid sequence of: VSQENPEMEGPERDQLVIPDGQEEEQEAAGEGR (hGP73 307-339).SELECTED DRAWING: Figure 1 【課題】ＧＰ７３分子上のフコース糖部分の存在もしくは不存在に感受性があり、ＧＰ７３のフコシル化形態に結合することができ、あるいは、ＧＰ７３分子上のフコース糖部分の存在または不存在に感受性がないが、ＧＰ７３および／またはフコシル化されたＧＰ７３を検出するためのイムノアッセイにおける使用に十分な結合親和性を有する抗ＧＰ７３モノクローナル抗体の提供。【解決手段】ＶＳＱＥＮＰＥＭＥＧＰＥＲＤＱＬＶＩＰＤＧＱＥＥＥＱＥＡＡＧＥＧＲ（ｈＧＰ７３、３０７−３３９）のアミノ酸配列内のエピトープに結合することができる単離された抗体または該抗体の抗体断片。【選択図】図１