COMPOUND FOR BORON NEUTRON CAPTURE THERAPY FOR AMYLOID β DISEASES

To provide a boron carrier compound having high binding specificity to an amyloid β protein, high permeability through the blood brain barrier, and a retention property in senile plaques in the brain, while having a property less likely to retain at a site other than senile plaques in the brain.SOLUTION: There are provided a compound for boron neutron capture therapy for amyloid β or pathological amyloid protein-related diseases containing a boron-10 atom in a flavone derivative, a chromone derivative, a coumarin derivative, an aurone derivative, a chalcone derivative, a benzothiazole derivative and a stilbene derivative, and use thereof.SELECTED DRAWING: None 【課題】アミロイドβ蛋白に対する高い結合特異性、高い血液脳関門の透過性、脳内老人斑内での貯留性を有し、一方、脳内老人斑以外の部位には残留しにくい特性を持つホウ素担体化合物を提供する。【解決手段】フラボン誘導体、クロモン誘導体、クマリン誘導体、オーロン誘導体、カルコン誘導体、ベンゾチアゾール誘導体及びスチルベン誘導体において、ホウ素−１０原子を各誘導体に含有するアミロイドβ又は病的アミロイド蛋白関連疾患に対するホウ素中性子捕捉療法用化合物及びその用途。【選択図】なし