5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR TREATMENT OF OSTEOARTHRITIS

To provide compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.SOLUTION: Th...

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Hauptverfasser:	MARIE LAURENCE CLAIRE VARIN, DAVID AMANTINI, CHRISTOPHE PEIXOTO, LUKE JONATHAN ALVEY, PIERRE MARC MARIE JOSEPH DEPREZ, FRANCK LAURENT BREBION, ROMAIN LUC MARIE GOSMINI, IULIANA ECATERINA POP-BOTEZ, HELENE MARIE JARY, FREDERIC ANDRE DE CEUNINCK
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.SOLUTION: There are provided a compound represented by ((S)-3-methyl-4-(5-methyl-pyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester, and a pharmaceutical composition comprising the same.SELECTED DRAWING: None 【課題】ADAMTSを阻害する化合物、その製造方法、それを含む医薬組成物、並びに炎症状態並びに/又は軟骨の分解及び/もしくは軟骨の恒常性の破壊を伴う疾患の予防及び/又は治療方法の提供。【解決手段】((S)-3-メチル-4-(5-メチル-ピリジン-3-イル)-ピペラジン-1-カルボン酸tert-ブチルエステルで例示される化合物、及びそれを含む医薬組成物。【選択図】なし