GLS1 INHIBITOR FOR TREATING DISEASES

GLS1 INHIBITOR FOR TREATING DISEASES

To provide a glutaminase inhibitor effective for GLSI inclusive diseases such as cancer, immune disorder, and neurological disorder.SOLUTION: There is provided a compound represented by the formula III, where n is 3, 4, or 5; Rand Rare alkyl, cyano, H or halogen, or the like; Ais C or N; A, A, and A...

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Hauptverfasser: LIU GANG, BARBARA CZAKO, ANNE YAU, TIMOTHY HEFFERNAN, MARIA EMILIAFRANCESCO, JASON P BURKE, LEE KANG, ZACHARY HERRERA, WYLIE S PALMER, JAY THEROFF, PHILIP JONES, RICHARD LEWIS, MICHAEL P SOTH, TIMOTHY MCAFOOS, MATTHEW M HAMILTON, CHRISTOPHER LAWRENCE CARROLL, KANG ZHIJUN
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:To provide a glutaminase inhibitor effective for GLSI inclusive diseases such as cancer, immune disorder, and neurological disorder.SOLUTION: There is provided a compound represented by the formula III, where n is 3, 4, or 5; Rand Rare alkyl, cyano, H or halogen, or the like; Ais C or N; A, A, and Aare N, O, S or CH;Zis C; Z, Z, Zare N or CH; and R, R, R, Rrepresent a specific substituent.SELECTED DRAWING: None 【課題】癌、免疫障害、及び神経障害等の、ＧＬＳＩ介在性障害に有効なグルタミナーゼ阻害薬の提供。【解決手段】式IIIで示される化合物。[式中、ｎは３、４、又は５；ＲＸ、ＲＹは、アルキル、シアノ、Ｈ又はハロゲン等；Ａ１はＣ又はＮ；Ａ２、Ａ３、Ａ４は、Ｎ、Ｏ、Ｓ又はＣＨ；Ｚ１はＣ；Ｚ２、Ｚ３、Ｚ４はＮ又はＣＨ；R1、R2、R3,R6は特定の置換基を表す]【選択図】なし