SEQUESTRANTS OF ADVANCED GLYCATION END PRODUCT (AGE) PRECURSORS

To provide sequestrants of novel AGE precursors.SOLUTION: The invention provides compounds including a structure of figure (I). The sequestrants of AGE precursors can be used as pharmaceutical agents and in pharmaceutical compositions. The sequestrants of AGE precursors are particularly useful in bi...

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Bibliographische Detailangaben
Hauptverfasser:	MILLER ROBER J, MAGNUS BESEV, STEPHEN RANDALL HOLMES-FARLEY, ANDREW T PAPOULIS, PRADEEP DHAL
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide sequestrants of novel AGE precursors.SOLUTION: The invention provides compounds including a structure of figure (I). The sequestrants of AGE precursors can be used as pharmaceutical agents and in pharmaceutical compositions. The sequestrants of AGE precursors are particularly useful in binding AGE precursors and dietary dicarbonyls in mammals in the gastrointestinal tract for treatment of diseases such as diabetic nephropathy, chronic renal disease, atherosclerosis, stroke, cataracts, and Alzheimer's disease.SELECTED DRAWING: None 【課題】新規ＡＧＥ前駆体の捕捉剤の提供。【解決手段】図（Ｉ）の構造を含む化合物。ＡＧＥ前駆体の捕捉剤は、医薬として、また医薬組成物に用いることができる。このＡＧＥ前駆体の捕捉剤は特に、糖尿病性腎症、慢性腎疾患、アテローム性動脈硬化症、脳卒中、白内障、およびアルツハイマー病のような病気の治療のために、哺乳動物の消化管中でＡＧＥ前駆体と食物性ジカルボニルを結合するのに有用である。【選択図】なし