PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF

To provide non-peptide linkers for ADCs.SOLUTION: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and the use in therapy for prevention or treatment of cancer.SELECTED DRAWING: None 【課題】ADCのための非ペプチドリンカーの提供。【解決手段】本発明...

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Hauptverfasser:	LUKE MASTERSON, THOMAS PILLOW, PHILIP WILSON HOWARD, JANET GUNZNER-TOSTE, WEI BINQING, LEANNA STABEN, ZHAO GUILING, JOHN FLYGARE, BRIAN SAFINA, VISHAL VERMA
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide non-peptide linkers for ADCs.SOLUTION: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and the use in therapy for prevention or treatment of cancer.SELECTED DRAWING: None 【課題】ADCのための非ペプチドリンカーの提供。【解決手段】本発明は、ペプチド模倣薬リンカーとその抗体−薬剤の複合体、それらを含有する薬学的な組成物及び癌の予防または治療のための治法における使用に関する。【選択図】なし