TRANSDERMAL PATCH FOR ADMINISTERING FENTANYL

To provide a method for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time.SOLUTION: A non-rate controlled, monolithic, subsaturated patch comprises (a) a backing layer and (b) a reservoir disposed on the backin...

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Bibliographische Detailangaben
Hauptverfasser:	LI SHAOLING, STEPIC JANE, OSDOL WILLIAM W VAN, VENKATRAMAN SUBRAMANIAN S, GALE ROBERT M
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide a method for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time.SOLUTION: A non-rate controlled, monolithic, subsaturated patch comprises (a) a backing layer and (b) a reservoir disposed on the backing layer. At least a skin-contacting surface of the reservoir is adhesive. The reservoir comprises a single-phase polymeric composition free of undissolved components and containing an amount of fentanyl or an analog thereof sufficient to induce and maintain analgesia in a human for at least three days.SELECTED DRAWING: None 【課題】長期間にわたり被験者に皮膚をとおして痛覚消失の目的のためにフェンタニルおよびその類似体を経皮的に投与するための方法の提供。【解決手段】速度制御されない、モノリスの亜飽和張り付け剤であって、（ａ）裏打ち層と、（ｂ）前記裏打ち層上に配置された貯蔵体、を有し、前記貯蔵体の少なくとも皮膚接触面が接着性であり、前記貯蔵体は、少なくとも３日間ヒトにおける痛覚消失を誘発し、維持するのに十分な量のフェンタニルまたはその類似体を含有する、非溶解成分を含まない単相ポリマー組成物を有する。【選択図】なし